This study aims to develop a user-centered clinical decision support tool to aid clinicians in early risk assessment and resource utilization in the management of agitated patients. By identifying risk factors that predict agitation (defined as excessive psychomotor activity leading to potential aggression or violence), our CDS tool can intervene to guide clinicians to use best practice strategies in the general, non-psychiatric emergency department (ED). The tool’s prediction model is based on real-world data and the prototype is being developed through user-centered design from clinician and patient input. Iterative feedback during all development phases and usability testing sessions will further refine the tool for improvement and feasibility. Our goal is to create a working, deliverable prototype of a CDS tool that can aid in agitation management prior to definitive psychiatric assistance.